The authors investigated diurnal change of urinary pH in control group and urine alkalizing group. The control group composed of normal group and hydration group (water 2000 cc/day). The urine alkalizing agent group composed of sodium bicarbonate group (4gm/day, 6mg./day, 8gm/day and 12gm./day) and citrate agent groups (Eisenberg`s solution; 60cc/day and CG-120 or Uralyt-U;4gm./day) in 15 normal healthy adult male.
The results were summarized as follows;
1. In normal control group and hydration group, diurnal urinary pH were 5.89+0.47 and 6.00 + 0.44 respectively, There was no significant difference between normal control group and hydration group (p<0.05).
2. In urine alkalizing agent foup, diurnal urinary pH of sodium bicarbicar-bonate groups (4gm./day, 6gm./day, 8gm./day and 12gm./day) were 6.26+0.51, 6.64+0.41, 6.74+0.53 and 7. 15+0.64 respectively, and diurnal urinary pH of citrate agent foups (Eisenberg`s solution and CG-120) were 7.04+0.78 and 6.48+0.60 respectively.
The urinary pH was increased about 0.1 every 1gm./day addition of sodium bicarbonate. For maintenance of urinary pH between 6.2-7.0 administration 4-8gm./day of sodium bicarbonate was favorable.
It was 5 times as much as CG-120 (4gm./day) in amount that Eisenberg`s solution contains 19.12gm of citrate in diurnal administration volume (60cc/day). So the augment effect of urinary pH of CG-120 was significantly great and its side effect was relatively less.
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